Takeda nearing preliminary agreement to buy Shire after sweetening offer

A blister pack containing Mezavant XL anti-inflammatory tablets, produced by Shire Plc, sits on a pharmacy counter in this arranged photograph in London, U.K., on Thursday, Dec. 29, 2016. Photographer: Chris Ratcliffe/Bloomberg

Takeda Pharmaceutical Co. is nearing a preliminary agreement to acquire Shire Plc after the Japanese drugmaker sweetened its roughly $60 billion bid for the biotechnology company, according to people with knowledge of the matter.

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